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Selon cette grande étude Danoise sur plus de 12 000 patients, on a conclu que le nouveau variant Omicron infecte 2.6 a 3.7 fois les vaccinés que les non vaccinés.
SARS-CoV-2 Omicron VOC Transmission in Danish Households
View ORCID ProfileFrederik Plesner Lyngse, View ORCID ProfileLaust Hvas Mortensen, View ORCID ProfileMatthew J. Denwood, View ORCID ProfileLasse Engbo Christiansen, View ORCID ProfileCamilla Holten Møller, View ORCID ProfileRobert Leo Skov, View ORCID ProfileKatja Spiess, View ORCID ProfileAnders Fomsgaard, Maria Magdalena Lassaunière, View ORCID ProfileMorten Rasmussen, View ORCID ProfileMarc Stegger, Claus Nielsen, View ORCID ProfileRaphael Niklaus Sieber, View ORCID ProfileArieh Sierra Cohen, Frederik Trier Møller, View ORCID ProfileMaria Overvad, View ORCID ProfileKåre Mølbak, View ORCID ProfileTyra Grove Krause, View ORCID ProfileCarsten Thure Kirkeby
Abstract
The Omicron variant of concern (VOC) is a rapidly spreading variant of SARS-CoV-2 that is likely to overtake the previously dominant Delta VOC in many countries by the end of 2021.
We estimated the transmission dynamics following the spread of Omicron VOC within Danish households during December 2021. We used data from Danish registers to estimate the household secondary attack rate (SAR).
Among 11,937 households (2,225 with the Omicron VOC), we identified 6,397 secondary infections during a 1-7 day follow-up period. The SAR was 31% and 21% in households with the Omicron and Delta VOC, respectively. We found an increased transmission for unvaccinated individuals, and a reduced transmission for booster-vaccinated individuals, compared to fully vaccinated individuals. Comparing households infected with the Omicron to Delta VOC, we found an 1.17 (95%-CI: 0.99-1.38) times higher SAR for unvaccinated, 2.61 times (95%-CI: 2.34-2.90) higher for fully vaccinated and 3.66 (95%-CI: 2.65-5.05) times higher for booster-vaccinated individuals, demonstrating strong evidence of immune evasiveness of the Omicron VOC.
Our findings confirm that the rapid spread of the Omicron VOC primarily can be ascribed to the immune evasiveness rather than an inherent increase in the basic transmissibility.
SARS-CoV-2 Omicron VOC Transmission in Danish Households
View ORCID ProfileFrederik Plesner Lyngse, View ORCID ProfileLaust Hvas Mortensen, View ORCID ProfileMatthew J. Denwood, View ORCID ProfileLasse Engbo Christiansen, View ORCID ProfileCamilla Holten Møller, View ORCID ProfileRobert Leo Skov, View ORCID ProfileKatja Spiess, View ORCID ProfileAnders Fomsgaard, Maria Magdalena Lassaunière, View ORCID ProfileMorten Rasmussen, View ORCID ProfileMarc Stegger, Claus Nielsen, View ORCID ProfileRaphael Niklaus Sieber, View ORCID ProfileArieh Sierra Cohen, Frederik Trier Møller, View ORCID ProfileMaria Overvad, View ORCID ProfileKåre Mølbak, View ORCID ProfileTyra Grove Krause, View ORCID ProfileCarsten Thure Kirkeby
Abstract
The Omicron variant of concern (VOC) is a rapidly spreading variant of SARS-CoV-2 that is likely to overtake the previously dominant Delta VOC in many countries by the end of 2021.
We estimated the transmission dynamics following the spread of Omicron VOC within Danish households during December 2021. We used data from Danish registers to estimate the household secondary attack rate (SAR).
Among 11,937 households (2,225 with the Omicron VOC), we identified 6,397 secondary infections during a 1-7 day follow-up period. The SAR was 31% and 21% in households with the Omicron and Delta VOC, respectively. We found an increased transmission for unvaccinated individuals, and a reduced transmission for booster-vaccinated individuals, compared to fully vaccinated individuals. Comparing households infected with the Omicron to Delta VOC, we found an 1.17 (95%-CI: 0.99-1.38) times higher SAR for unvaccinated, 2.61 times (95%-CI: 2.34-2.90) higher for fully vaccinated and 3.66 (95%-CI: 2.65-5.05) times higher for booster-vaccinated individuals, demonstrating strong evidence of immune evasiveness of the Omicron VOC.
Our findings confirm that the rapid spread of the Omicron VOC primarily can be ascribed to the immune evasiveness rather than an inherent increase in the basic transmissibility.
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